Acúmulo de 131INa en quistes renales sin relación con enfermedad metastásica en un paciente con carcinoma diferenciado de tiroides / Accumulation of 131INa activity in renal cysts unrelated to metastatic disease in a patient with differentiated thyroid cancer

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SPECT-TC con 111In-octreotide en paragangliomas de cabeza y cuello / 111In-octreotide SPECT-CT in head and neck paragangliomas

Los paragangliomas de cabeza y cuello son tumores neuroendocrinos poco frecuentes, que expresan receptores para la somatostatina (RSS) en su superficie celular, particularmente el subtipo 2. Por esta particularidad, en la Medicina Nuclear es posible obtener imágenes de los mismos mediante la utilización de análogos sintéticos de la somatostatina, principalmente el octreotide, el cual tras su radiomarcaje con 111In o 68Ga, permiten su visualización selectiva, bien por imágenes gammagráficas planares, SPECT-TC o PET-TC. De una serie de pacientes se seleccionan y presentan 3 casos que ilustran la utilidad de los estudios SPECT-TC con 111In-octreotide en el diagnóstico y seguimiento de este tipo de tumor: caracterización y diagnóstico inicial, estadificación y detección de recurrencia local o metástasis, y su valor añadido respecto a las imágenes anatómicas (resonancia magnética, tomografía computarizada, angiografía), por ejemplo en la diferenciación entre tejido funcional o cicatricial en los pacientes sometidos previamente a cirugía (AU)

Head and neck paragangliomas are rare neuroendocrine tumors expressing somatostatin receptors on their cell surface, particularly subtype 2. Due to this distinctive feature, images can be obtained in Nuclear Medicine using synthetic analogues of somatostatin, mainly octreotide, which allow selective display by planar scintigraphy, SPECT-CT or PET-CT imaging after radiolabeling with 111In or 68Ga. Three cases have been selected and presented from a series of patients that illustrate the utility of SPECT-CT studies with 111In-octreotide in the diagnosis and monitoring of this type of tumor. These are characterization at initial diagnosis, staging, and detection of local recurrence or metastasis, with added value with respect to anatomical images (nuclear magnetic resonance, computed axial tomography, angiography), for example in the differentiation between functional tissue or scar in patients who had previously undergone surgery (AU)

(111)In-octreotide SPECT-CT in head and neck paragangliomas.

Head and neck paragangliomas are rare neuroendocrine tumors expressing somatostatin receptors on their cell surface, particularly subtype 2. Due to this distinctive feature, images can be obtained in Nuclear Medicine using synthetic analogues of somatostatin, mainly octreotide, which allow selective display by planar scintigraphy, SPECT-CT or PET-CT imaging after radiolabeling with (111)In or (68)Ga. Three cases have been selected and presented from a series of patients that illustrate the utility of SPECT-CT studies with (111)In-octreotide in the diagnosis and monitoring of this type of tumor. These are characterization at initial diagnosis, staging, and detection of local recurrence or metastasis, with added value with respect to anatomical images (nuclear magnetic resonance, computed axial tomography, angiography), for example in the differentiation between functional tissue or scar in patients who had previously undergone surgery.

[Prognostic value of the ultrasound and diuretic renogram in the evolution of ureteropelvic junction obstruction]. / Valor pronóstico de la ecografía y el renograma diurético en la evolución de la estenosis pieloureteral.

INTRODUCTION: The congenital obstruction of the pieloureteral junction (UPJ) is the most frequent cause of hydronephrosis in children. Sometimes, establishing the convenience of a surgical procedure is difficult, mainly if we consider the literature published on the spontaneous resolution of the slight, moderate and even severe hydronephrosis in newborns. OBJECTIVE: To determine the prognostic value of ultrasound in the evolution of the unilateral hydronephrosis, by assesing the size of the contralateral kidney. To verify if the "supranormal" renal function (SRF) is real or an artefact. PATIENTS AND METHODS: We have performed a descriptive observational study over a 10 years period (1995-2005). The study included all patients with the only diagnosis of obstructive unilateral hydronephrosis that underwent pieloplasty, and were controlled for 1 year period after the surgical treatment. RESULTS: Of the 66 patients in the study, 42 were boys (63.6%) and 24 girls (36.4%). After the first diuretic renogram (DR), in 57 of the patients (86.4%) the clearance half-time (T1/2) was over 20 minutes, in 6 cases (9.1%) it was 10-20 minutes and only in 3 cases it was shorter than 10 minutes. A similar differential renal function (FRD) was observed in the moderate and severe hydronephrosis. Supranormal function (FRD > 52%) was detected on DR in 11 patients, predominating in left hidronefrosis, and in more than 50% of the cases this value it did not agree with the renal function measured by dimercapto-succinic acid (DMSA), Pearson's correlation coefficient: 0.19. These kidneys experienced a greater reduction of the postoperative renal function. CONCLUSIONS: In the unilateral obstructive hydronephrosis, the healthy contralateral kidney experiences hypertrophy detectable by ultrasound, but these ecographic diameters are within the band of individual confidence of the healthy children of reference. The supranormal function exists, but in most cases it is an artefact.

Valor pronóstico de la ecografía y el renograma diurético en la evolución de la estenosis pieloureteral / Prognostic value of the ultrasound and diuretic renogram in the evolution of ureteropelvic junction obstruction

Introducción. La obstrucción congénita de la unión pieloureteral(EPU) es la causa más frecuente de hidronefrosis en el niño. A veces, establecer la indicación quirúrgica es difícil, sobre todo si tenemos en cuenta la literatura publicada sobre la resolución espontánea de la hidronefrosis leve, moderada e incluso grave en el periodo neonatal. Objetivo. Determinar el valor pronóstico de la ecografía en la evolución de la hidronefrosis unilateral, monitorizando el tamaño del riñón contralateral. Comprobar si la función renal “supranormal” (FRS) es real o un artefacto. Pacientes y métodos. Realizamos un estudio observacional descriptivo que abarca 10 años (1995-2005). Se han considerado a efectos del estudio a todos los pacientes pediátricos con diagnóstico de hidronefrosis obstructiva que fueron sometidos a una pieloplastia, y controlados durante un período mínimo de 1 año tras el tratamiento quirúrgico. Resultados. De los 66 pacientes revisados 42 eran niños (63,6%)y 24 niñas (36,4%). Tras el primer renograma diurético (RD), en 57pacientes (86,4%) el tiempo medio de eliminación (T1/2) estaba por encima de los 20 minutos, en 6 casos (9,1%) estaba entre 10-20 minutos y sólo en 3 casos era menor de 10 minutos. Se observó una función renal diferencial (FRD) similar en las hidronefrosis moderadas y graves. En 11 pacientes encontramos una FRS (FRD>52%) renográfica, predominando en las hidronefrosis izquierdas, y en más del 50% de los casos este valor no coincidía con la FRD gammagráfica con ácido dimercaptosuccínico (DMSA), coeficiente de correlación de Pearson: 0,19. Estos riñones con FRS preoperatoria experimentaron un mayor descenso de la función renal postoperatoria. Conclusiones. En las hidronefrosis obstructivas el riñón contralateral sano experimenta una hipertrofia apreciable en la ecografía, pero estos diámetros ecográficos están dentro de la banda de confianza individual de la población sana de referencia. La función supranormal existe, pero en la mayoría de los casos es un artefacto (AU)

Introduction. The congenital obstruction of the pieloureteral junction(UPJ) is the most frequent cause of hydronephrosis in children. Sometimes, establishing the convenience of a surgical procedure is difficult, mainly if we consider the literature published on the spontaneous resolution of the slight, moderate and even severe hydronephrosis in newborns. Objective. To determine the prognostic value of ultrasound in the evolution of the unilateral hydronephrosis, by assessing the size of the contralateral kidney. To verify if the “supranormal” renal function(SRF) is a real or an artefact. Patients and methods. We have performed a descriptive observational study over a 10 years period (1995-2005). The study included all patients with the only diagnosis of obstructive unilateral hydronephrosis that underwent pieloplasty, and were controlled for 1 year period after the surgical treatment. Results. Of the 66 patients in the study, 42 were boys (63.6%) and24 girls (36.4%). After the first diuretic renogram (DR), in 57 of the patients (86.4%) the clearance half-time (T1/2) was over 20 minutes, in6 cases (9.1%) it was 10-20 minutes and only in 3 cases it was shorter than 10 minutes. A similar differential renal function (FRD) was observed in the moderate and severe hydronephrosis. Supranormal function (FRD>52%)was detected on DR in 11 patients, predominating in left hidronefrosis, and in more than 50% of the cases this value it did not agree with the renal function measured by dimercapto-succinic acid (DMSA), Pearson’s correlation coefficient: 0.19. These kidneys experienced a greater reduction of the postoperative renal function. Conclusions. In the unilateral obstructive hydronephrosis, the healthy contralateral kidney experiences hypertrophy detectable by ultrasound, but these ecographic diameters are within the band of individual confidence of the healthy children of reference. The supranormal function exists, but in most cases it is an artefact (AU)

[Brain perfusion SPECT in the prognostic assessment of stroke]. / SPECT de perfusión cerebral en la valoracion pronóstica del ictus.

PURPOSE: To compare the diagnostic yield of CT scan and perfusion SPECT on admission and its prognostic value in clinical outcome. METHODS: 25 ischemic stroke cases were studied on admission (<24 h) and at 30-60 days by CT scan, 99mTc-HMPAO-SPECT and neurological scales. Infarct size and severity on SPECT were assessed: visually "Total Weighted Score," added value in 22 areas, and by several semiquantitative count-based indices. RESULTS: Sensitivity: the first CT scan was positive in 24% patients, initial SPECT in 75% (73% of pure subcortical infarcts and 91% of those with cortical involvement). Localization: kappa: 0.725 between SPECT findings on admission and those in control-CT at 5 days. Extent and severity: correlations between count-based and visual indices (r: >0.719), the latter correlated slightly better with clinical scales. Both predicted similarly (Rho>0.739) infarct size in CT diagnostic scan. Early Outcome: There were statistical differences between deceased and survivors in SPECT (<24h) indices and CT-infarct size (mean 5 days), but not in neurological scores on admission. Long term Outcome: Correlation of initial SPECT indices with follow-up functional scores (SNSLP, Barthel index; mean 37 days) was only significant for visual SPECT indices (Rho:0.560 to 0.620). Nevertheless the best predictor of functional status on discharge was the Barthel Index on admission. CONCLUSIONS: 1) Early SPECT has good sensitivity and accurate infarct size prediction so it can be a useful tool for deciding thrombolytic therapy; 2) Visual scores perform as well as more complex indices; 3) Infarct volume seems to be a critical determinant in vital outcome; other factors (strategic localization, etc.) might influence long term functional status.

SPECT de perfusión cerebral en la valoracion pronóstica del ictus / Brain perfusion spect in the prognostic assessment of stroke

Objetivo: Comparar el rendimiento de la TC y SPECT de perfusión iniciales y su valor pronóstico respecto a la evolución posterior. Métodos: 25 ictus isquémicos evaluados en su admisión ( 0,719); éstos con ligera mejor relación con escalas clínicas. Similar predicción por ambos del tamaño del infarto (Rho > 0,739). Pronóstico inicial: Se observaron diferencias estadísticas entre fallecidos y supervivientes en los índices de la SPECT inicial y en el tamaño del infarto (TC a mediana de 5 días), pero no en la valoración clínica inicial. Pronóstico a largo plazo: La correlación de la SPECT inicial con el estado funcional al mes sólo fue significativa en los índices visuales (Rho: -0,620). Sin embargo el mejor predictor del estado funcional definitivo fue el Barthel al ingreso. Conclusiones: 1) La SPECT inicial ofrece una buena sensibilidad y predicción del tamaño del infarto; 2) Los índices visuales presentan un rendimiento similar a los más complejos; 3) El volumen del infarto parece ser un determinante critico en el pronóstico vital; otros factores podrían influenciar el estado funcional a largo plazo (AU)